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By this way urea recirculates repeatedly and helps to maintain the hyperosmolarity of inner medullary interstitium gastritis causes phenazopyridine 200 mg buy without prescription. It is responsible for the maintenance of medullary gradient, which is developed by countercurrent multiplier (Fig. Role of Vasa Recta in the Maintenance of Medullary Gradient Vasa recta acts like countercurrent exchanger because of its position. Its descending limb runs along the ascending limb of Henle loop and its ascending limb runs along with descending limb of Henle loop. The sodium chloride reabsorbed from ascending limb of Henle loop enters the medullary interstitium. Simultaneously water diffuses from descending limb of vasa recta into medullary interstitium. So, a large quantity of sodium chloride accumulates in descending limb of vasa recta and flows slowly towards ascending limb. By the time the blood reaches the ascending limb of vasa recta, the concentration of sodium chloride increases very much. Simultaneously, water from medullary interstitium enters the ascending limb of vasa recta. If the vasa recta would be a straight vessel without hairpin arrangement, blood would leave the kidney quickly at renal papillary level. Numerical indicate osmolarity (mOsm/L) interstitium and thereby the hyperosmolarity will be decreased. Therefore, when blood passes through the ascending limb of vasa recta, sodium chloride diffuses out of blood and enters the interstitial fluid of medulla and, water diffuses into the blood. Thus, vasa recta retains sodium chloride in the medullary interstitium and removes water from it. The blood passing through the ascending limb of vasa recta may carry very little amount of sodium chloride from the medulla. From medullary interstitium, along with sodium chloride, urea also enters the descending limb of vasa recta. When blood passes through ascending limb of vasa 328 Section 5 t Renal Physiology and Skin recta, urea diffuses back into the medullary interstitium along with sodium chloride. Thus, sodium chloride and urea are exchanged for water between the ascending and descending limbs of vasa recta, hence this system is called countercurrent exchanger.

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